Dr. najmeh Heusch
Angestellt, Researcher, IFIB, university of Tübingen
Tübingen, Deutschland
Über mich
- Experienced Researcher with a demonstrated history of working in the higher education University. - great interest for the scientific community and eager to learn novel techniques to enhance my knowledge in science. - High level of team work as well as the ability to work independently and very good organization skills. - research professional Skilled in: - In vitro cultures: Cell, tissue and organ cultures and Plant breeding. -Metabolomics: Natural compounds extraction from plant, working with HPLC, preparative LC, MS-LC and Familiar with NMR, FT-IR, CD spectrometry. - strong background in molecular biology, plant transformation and expertise in RNAi technologies, DNA and RNA Extraction, qPCR, RT-PCR, gel electrophoresis and etc. - Molecular cloning and recombinant genes expression, Protein purification, FPLC, Crystallography, Enzyme assays, Western blotting, ELISA. - Bio production of plant natural products in 10 L Bioreactor.
Werdegang
Berufserfahrung von najmeh Heusch
Bis heute 5 Jahre und 7 Monate, seit Dez. 2018
Researcher
IFIB, university of Tübingen
Main Topic: Genetic manipulation of the lignan biosynthesis pathway in Linum album: - using RNAi technology for the suppression of candidate gene to increase the biosynthesis of podophyllotoxin; a plant natural product, belonging to the lignan family, which constitutes the unique precursor of etoposide, a topoisomerase II inhibitor drug, used in an anticancer chemotherapy treatments appearing on the WHO list of essential medicines.
4 Jahre und 1 Monat, Sep. 2014 - Sep. 2018
Assistant Professor
University of Mazandaran, Iran
- Supervised bachelor, master and PhD projects and trained students in in-vitro cultures and molecular and biochemical techniques. - teaching in several areas of plant biology for undergraduates and graduates students - holding biology seminars and molecular workshops (cloning) - research in secondary metabolites pathways, especially lignan biosynthesis pathway - collaboration in different projects at IFIB (traveling to Germany)
Ausbildung von najmeh Heusch
1 Jahr und 7 Monate, März 2012 - Sep. 2013
Plant biochemistry
IFIB, University of Tübingen,
1) Biochemical characterization of a pinoresinol lariciresinol reductase like protein: - Heterologous expression of the protein in E. coli - Purification of the protein by Ni-NTA affinity chromatography and gelfiltration - Determination of the enantiospecifiity - Determination of enzyme kinetic parameters - Protein crystallography for the determination of the 3D protein structure 1) Genetic manipulation of the lignan biosynthesis in hairy roots: - Cloning of RNAi vector constructs
5 Jahre und 7 Monate, Sep. 2007 - März 2013
Plant physiology
Tarbiat Modares University, Tehran, Iran
Biosynthesis of lignans under coniferaldehyde and methyl jasmonate treatments in hairy roots of Linum album
Sprachen
Englisch
Fließend
Deutsch
Gut
persian First language
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